Test Name Result AB Normal Range Units
IGG 466 L 600-1700 MG/DL
IGM 31 L 35-290 MG/DL
IGA 408 H 40-400 MG/DL
Electrophoresis
The SPE pattern demonstrates two bands of restricted mobility in the gamma region.
Immunofix, Serum
Monoclonal component typed as IgA Lambda. Concentration of monoclonal protein determined by serum protein electrophoresis is 0.4 g/dL.
Monoclonal component typed as IgA Lambda. Concentration of monoclonal protein determined by serum protein electrophoresis is 0.3 g/dL.
*Suggestive of a monoclonal component typed as IgG Kappa. Concentration of monoclonal protein is too low to accurately quantify.
* This is new! Previously, I’ve only ever had just two m-spikes. That’s not enough? I vaguely remember seeing this on one other report, so maybe it’s something that comes and goes. In any case, it’s not enough to measure, so I’m not alarmed.
Serum Free Light Chain Assay
Test Name Result AB Normal Range Units
Kappa Free, Serum 0.1380 L 0.33-1.94 mg/dL
Lambda Free, Serum 1.24 0.57-2.63 mg/dL
K/L FLC Ratio 0.1113 L 0.26-1.65 mg/dL
I don’t have a lot to blog about here because my myeloma has been stable since last fall. There’s not much there at all. If you don’t have myeloma, I have only a little bit more than you do.
These labs were done 12/08/2008
IFE SERUM
(2) MONOCLONAL IgA-LAMBDAS DETECTED BY IFE.
SPE M-SPIKE 1 0.17 g/dL
SPE M-SPIKE 2 0.12 g/dL
IG FREE LIGHT CHAINS SERUMReference
IG FREE LIGHT CHAIN KAPPA *0.16mg/dL [0.33-1.94]
IG FREE LIGHT CHAIN LAMBDA 1.85mg/dL [0.57-2.63]
IG FLC KAPPA/LAMBDA RATIO *0.09 [0.26-1.65]
IMMUNOGLOBULIN PROFILE
IMMUNOGLOBULIN G *374mg/dL [588-1573]
TEST REPEATED TO CONFIRM
IMMUNOGLOBULIN A *415mg/dL [46-287]
TEST REPEATED TO CONFIRM
IMMUNOGLOBULIN M *31mg/dL [57-237]
TEST REPEATED TO CONFIRM
IMMUNOGLOBULIN E 13 IU/mL [4-269]
On the mailing list we had a discussion about bone disease in MM. Here’s what Nancy said about it. I hadn’t realized before that IgA patients are less prone to bone disease. One of my doctors did tell me we’re more likely to have kidney involvement though.
Some people never have bone disease…that’s just the way their myeloma is; just as some people never have kidney problems. The names given to the variations of myeloma are not different. Patients with IgA myeloma are less likely to have bone disease than those with IgG myeloma…and those with IgG myeloma are less like than those with IgA myeloma (or Bence Jones myeloma) to have kidney problems.
Perhaps by “classic myeloma” they are referring to myeloma that is in the bone marrow…as opposed to extramedullary myeloma which is outside the bone marrow….rather than affecting the bones. However, about 80% of patients do have bone involvement, so it is the most common symptom of myeloma.
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